Fig.4-15 DNA strand breaks in mitochondria of mammalian cells following γ ray irradiation

Fig.4-15 DNA strand breaks in mitochondria of mammalian cells following γ ray irradiation

Radiation-induced DNA strand breaks in mitochondria of mammalian cells were visualized by employing PprA protein using an immunofluorescence technique. Colocalization of fluorescence breaks and mitochondria was observed in the image merging the two (right panel). This image suggests that DNA strand breaks existing in mitochondria were effectively detected by utilizing DNA strand break binding ability of PprA protein.

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