In order to design an advanced nuclear fuel-cycle system, the fundamental process, apparatus arrangement, and material flow have to be clarified. At this time, the measurement accuracy of Pu is achieved with a Nuclear Material Accounting core in a simulator, abnormal event detection with a Multivariate and Multi-scale core, and optimal selection of safeguards apparatus with a Multiple Objective Optimization core. A Virtual Design core will enable us to investigate the safeguards system even in the facility design phase.