The quadrupole present prior to the collision reaction cell (CRC) removes ²³⁸U to avoid the creation of ²³⁸UO₂ hydride at the CRC. Pu, Am, and Cm react with CO₂ at the CRC. Pu passes through the quadrupole of the back end of the dynamic reaction cell (DRC) as a dioxide, while Am and Cm are removed as monoxides. By this technique, Pu isotopes (²³⁹Pu, ²⁴⁰Pu, ²⁴¹Pu, ²⁴²Pu, and ²⁴⁴Pu) can be simultaneously detected via one-shot data acquisition.